A new study, "Identifying Allosteric Hotspots in Mycobacterium tuberculosis cAMP Receptor Protein" published in Biochemistry, provides key insights into how bacterial cAMP receptor proteins (CRPs) ...
Transcription factors and other allosteric cell signaling proteins contain a disproportionate number of domains or segments that are intrinsically disordered (ID) under native conditions. In many ...
Washington, D.C. – A new study, “Identifying Allosteric Hotspots in Mycobacterium tuberculosis cAMP Receptor Protein” published in Biochemistry, provides key insights into how bacterial cAMP receptor ...
EPFL scientists have created a new computer model that can help better design of allosteric drugs, which control proteins "at a distance". Enzymes are large proteins that are involved in virtually ...
Sir2, an enzyme belonging to sirtuins, has been effectively involved in the deacetylation of proteins. A tandem allosteric effect of reactant and product is responsible for the efficient deacetylation ...
19don MSN
Bacterial species study challenges assumption that structural similarity predicts protein behavior
A new study published in Biochemistry sheds light on how bacteria regulate their genes, challenging long-held assumptions ...
Serotonergic G-protein-coupled receptors (GPCRs), including the 5-HT2A receptor (5-HT2AR) and 5-HT2CR, are key regulators of cortical signaling pathways and promising targets for neurotherapeutic drug ...
In this Innovation Spotlight, Gene Mack, the chief executive officer of Gain Therapeutics, discusses the company’s Magellan™ platform, which uss machine learning and structural modeling to identify ...
Cancer is one of the leading causes of death worldwide, affecting over 20 million individuals and killing 9.7 million in 2022 alone. Each of ~200 cancer types (and multiple subtypes) presents an ...
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