Protein disaggregation is a critical cellular process wherein misfolded or aggregated proteins are solubilised and, in many cases, returned to their native configurations. Chaperone systems, including ...

Chaperone protein imbalance can play a significant role in initiating toxic accumulation of tau in the aging brain - an early step in the development of Alzheimer's disease and related ...

Protein aggregation is a continuous cellular process and may be a result of misfolding caused by various stressors. Chaperone complexes, in conjunction with interacting ubiquitin E3 ligases, channel ...

In many neurodegenerative diseases like Parkinson's, protein aggregates form in the brain and are assumed to contribute to neuronal cell death. Yet there exists a cellular defense mechanism that ...

Proteins are the molecular machines of cells. They are produced in protein factories called ribosomes based on their blueprint—the genetic information. Here, the basic building blocks of proteins, ...

Among the hallmarks of Alzheimer's disease are the Alzheimer fibrils, deposits of the tau protein, which accumulate in nerve cells in the form of fibres and disrupt communication between nerve cells.

The biology of histone proteins encompasses their synthesis in the cytosol, nuclear import and incorporation into nucleosomes, as well as subsequent eviction from chromatin, redeposition, storage or ...

Researchers from the Keck School of Medicine of USC used imaging techniques to study how the protein GRP78 controls cancer cell behavior. In the top row, human lung cancer cells were engineered to ...

In many neurodegenerative diseases, proteins clump in the brain, forming so-called amyloid fibrils. Yet there exists a cellular defence mechanism that counteracts this process and even dissolves ...