Activating the cell surface receptor TREM2 rallies microglia to clear amyloid plaques. Can activating a kinase downstream of TREM2 do the same? Two groups of scientists say yes. In the October 26 Cell ...

Serendipitously discovered as an antifungal agent from soil samples, rapamycin is used as an immunosuppressant in patients with transplantation, cancer, and neurological disorders, and is believed to ...

Certain variants in the TREM2 gene more than triple a person’s risk of AD, seemingly by sapping the protective function this microglial receptor performs. According to findings presented at the ...

Fig 1. PI3K/AKT/mTOR signaling pathway showing interacting activation and regulatory feedback loops. Adapted from Hoeffer and Klann. 35 Mammalian target of rapamycin (mTOR) is a serine-threonine ...