It's hard to picture anyone else taking on the role.

Rob Lowe explains why he declined the role of Derek Shepherd on Grey’s Anatomy, how Patrick Dempsey was cast, and what happened during the show’s early casting process ...

Patrick Dempsey Reflects on Eric Dane’s Battle With ALS and Their Last Conversations When news of his passing spread i ...

Depp reportedly loaned his Los Angeles property to Dane to ease the "Grey's Anatomy" star's financial burden amid his ALS ...

Heigl joins several of Dane’s co-stars who have paid tribute to the late actor after his death. Patrick Dempsey, who played ...

Patrick Dempsey stepped out with wife Jillian and daughter Talula ahead of the 2026 BAFTA Awards. The trio attended a pre-BAFTA party on Feb. 21, before Patrick and Talula, 24, attended the awards ...

Body language experts say the actor showed subtle signs of grief while staying composed during his first major event after Dane’s passing ...

"Grey's Anatomy" actress Katherine Heigl shared an emotional tribute to her late co-star Eric Dane on Sunday. (AP Photo) ...

His career took off after he emerged from a shower with a strategically placed towel on the ABC hit. Later, he starred on ...

After Dane’s episode of Famous Last Words dropped on Netflix, his Euphoria co-stars shared clips. Both Sydney Sweeney and ...