γ-secretase may have been one of the first intramembrane proteases to be described, but since its discovery a host of these special cutters have been identified in organisms from bacteria on up. But ...

A team of Chinese scientists has recently developed two novel compounds that inhibit the SARS-CoV-2 main protease (M pro) and one of them is a good drug candidate for further clinical studies. The ...

Telaprevir now binds less tightly to the protease (it is a poorer inhibitor). English translation: A single mutation in the structure at the telaprevir binding site on the protease weakens the binding ...

The structure of enzymes determines how they control vital processes such as digestion or immune response. This is because the protein compounds are not rigid, but can change their shape through ...

Pfizer's Paxlovid looks very promising in fighting COVID. It also provides a good opportunity to learn about how enzyme inhibitors work. For masochists only. Although different chemists may have other ...