Researchers led by Brian Hoffman of Northwestern University and Michael Daly of the Uniformed Services University have ...

How HRD and BRCA results steer frontline ovarian cancer maintenance—niraparib vs olaparib—plus guidance on recurrence, ...

As is often the case with cancer treatments, many patients are able to benefit from therapy for a time. Tumor activity ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal metabolic processes or external stressors such as radiation or chemical ...

A new study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most powerful genetic "on switches" in cancer cells, called super-enhancers, drive ...

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among the most dangerous forms of DNA damage and immediately trigger the cell's ...

“By enhancing DNA repair, we can heal tissue damage that occurs during a heart attack,” Ibrahim said. “We are particularly excited because TY1 also works in other conditions, including autoimmune ...

Scientists have created a live-cell DNA sensor that reveals how damage appears and disappears inside living cells, capturing the entire repair sequence as it unfolds. Instead of freezing cells at ...

Version of Record: This is the final version of the article. The cohesin complex is essential for maintaining sister chromatid cohesion from S phase until anaphase. Beyond this canonical role, it is ...

In experiments, researchers showed that the disease-spreading insects couldn’t resist the sweet smell of a fungus that infected and killed them. By Jason P. Dinh Watch your back, DEET. There’s a new ...

A new study reports that four amino acid changes in a single protein help the naked mole rat repair DNA more efficiently. The same rodent can live up to about 37 years in captivity, far longer than ...