Abstract: The present study aimed to analyze the morphological and mechanical changes in neutrophils associated with infectious septic complications and IRF5 gene knockdown in macrophages. In our ...

Mutations in a gene associated with Crohn's disease have been found to rob critical immune cells of their ability to switch modes, causing them to overreact and trigger inflammation. Variations in the ...

UC San Diego researchers combined artificial intelligence with molecular biology to unravel how immune cells in the gut decide between inflammation and healing, a process gone awry in Crohn’s disease.

For decades, a piece of the puzzle has been missing in the study of Crohn’s disease and how it develops in the body. But a recent discovery from researchers at the UC San Diego School of Medicine in ...

Your gut harbors trillions of microbes which live in precarious harmony with your immune system. When that harmony is upset, the results can be excruciating—especially for those with Crohn’s disease, ...

A team at UC San Diego used artificial intelligence and molecular biology to unravel how the immune system’s gut macrophages decide whether to fight infection or heal tissue. Credit: Shutterstock UC ...

Co-first author Mahitha Shree Anandachar (center), a Ph.D. student in Biomedical Sciences at UC San Diego, with student research assistant Jasmin Salem (left) and Pradipta Ghosh, M.D. (right). The ...

WATERTOWN, Mass., Oct. 27, 2025 (GLOBE NEWSWIRE) -- Kymera Therapeutics, Inc. (NASDAQ: KYMR), a clinical-stage biopharmaceutical company advancing a new class of oral small molecule degrader medicines ...

UC San Diego researchers have settled a decades-long debate surrounding the role of the first Crohn’s disease gene to be associated with a heightened risk for developing the auto-immune condition.

The journal retracts the August 24, 2021 article cited above. Following publication, concerns were raised regarding the integrity of the images in the published figures. The authors failed to provide ...

ABSTRACT: Osteoarthritis (OA) is a degenerative joint disease that is common and significantly impacted in middle-aged and elderly people, and its accompanying inflammatory response plays a crucial ...

Kymera specializes in targeted protein degradation (TPD), a novel drug discovery approach that uses small molecules to direct the body’s cellular machinery to eliminate proteins involved in disease.