Somatic Mutation vs. Germline Mutation - Cleveland Clinic
May 24, 2022 · Germline mutations occur in a parent’s reproductive cells (egg or sperm). These mutations change the genetic material that the child receives from their parent (hereditary).
Germline mutation - Wikipedia
A mutation that arises only in germ cells can result in offspring with a genetic condition that is not present in either parent; this is because the mutation is not present in the rest of the parents' body, …
What Are Germline Mutations and How Are They Inherited?
Aug 1, 2025 · Germline mutations are distinct from somatic mutations in several fundamental ways, primarily concerning their origin, location, and heritability. Germline mutations arise in the …
Germline Mutations: Many Roles in Leukemogenesis - PMC
The purpose of this review is to summarize the current understanding of germline mutations as they contribute to leukemia development and progression. We also discuss how these new insights may …
Definition of germline mutation - NCI Dictionary of Cancer Terms
A gene change in a body's reproductive cell (egg or sperm) that becomes incorporated into the DNA of every cell in the body of the offspring. Germline mutations are passed on from parents to offspring.
Germline vs. Somatic Mutations: What’s the Difference?
Germline mutations originate in reproductive cells, are present in every cell if inherited, and are passed down to offspring. In contrast, somatic mutations occur in non-reproductive body cells, affect only a …
Somatic vs. Germline Mutations
• Germline testing helps to identify patients that may be candidates for a different surgery if they have a hereditary cancer syndrome that places them at a high risk to develop cancer again
Germline vs Somatic Mutations: Key Differences and Implications ...
Apr 29, 2025 · Germline mutations occur in reproductive cells and can be passed to offspring, whereas somatic mutations arise in non-reproductive cells and affect only the individual. These distinctions …
Definition of germline mutation - NCI Dictionary of Genetics Terms
A mutation in a reproductive cell (egg or sperm) that is in the DNA of every cell in the offspring's body. A mutation contained within the germline can be passed from parent to offspring and is, therefore, …
Germline genetic variation impacts clonal hematopoiesis ... - Nature
Jul 15, 2025 · Germline genetic variation influences cancer risk and shapes tumor mutational profile, but its influence on the mutational landscape of normal tissues is not well known. Here we studied the...