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The Wolff–Kishner reduction enables the complete deoxygenation of aldehydes and ketones to alkanes via hydrazone formation under strongly basic, high-temperature conditions. Developed by Ludwig Wolff and Nikolai Kishner in the early 20th century, the reaction proceeds through base-induced decomposition of the hydrazone with loss of dinitrogen, providing a thermodynamically driven reduction pathway. Learn. Review. Repeat.
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